Applies to the following strength(s): 2 mg/m L ; 5 mg/m L ; 1 mg/m L ; 1 mg/m L preservative-free ; 5 mg/m L preservative-free ; 1 mg/m L-Na Cl 0.9% ; 1 mg/m L-D5% ; 1 mg/m L preservative-free-D5% ; 0.5 mg/m L-D5% ; 0.5 mg/m L preservative-free-D5% ; 0.5 mg/m L-Na Cl 0.9% ; 2 mg/m L-Na Cl 0.9% The information at is not a substitute for medical advice. Patients younger than 60 years: IM: -Usual dose: 0.07 to 0.08 mg/kg IM once, up to 1 hour before surgery IV: -Usual dose: 1 to 2.5 mg slow IV every 2 minutes as necessary for sedation -Maintenance dose: After thorough clinical evaluation, additional doses may be given in increments of 25% of the initial dose used to reach sedation.
The American Society of Anesthesiologists (ASA) has responded to this challenging responsibility by developing practice guidelines for nonanesthesiologists who provide sedation and analgesia.
There is some overlap between the terms "sedative" and "hypnotic".
Advances in pharmacology have permitted more specific targeting of receptors, and greater selectivity of agents, which necessitates greater precision when describing these agents and their effects: Doctors often administer sedatives to patients in order to dull the patient's anxiety related to painful or anxiety-provoking procedures.
Most veterinarians would recommend skipping oral sedatives and going right to injectable medications as they have a more predictable response.
Use care, have the owner muzzle the dog at home, and warn the client of all the risks associated with sedating an aggressive dog (including death). Erratum in: J Am Vet Med Assoc 1998 Oct 15;213(8):1170.
Here are some options for oral medications if you find yourself in need of this information.
Comparison of five regimens for oral administration of medication to induce sedation in dogs prior to euthanasia.
Sedatives can be misused to produce an overly-calming effect (alcohol being the classic and most common sedating drug).
In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness (see hypnotic) and even death.
At higher doses it may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes.
Doses of sedatives such as benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect.
As veterinarians, all too often we are called upon to vaccinate, examine, or otherwise deal with dogs who are aggressive, fearful, poorly trained, not properly socialized, or all of the above.